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Gist Overview - GIST often spreads from the original site to distant locations. Gastrointestinal stromal tumors belong to a group of cancers called soft tissue sarcomas. Sarcomas are a rare type of cancer that can occur in connective tissues, bones, muscles, fat, nerves, blood vessels, and cartilage. GIST tumors often grow quite large before they are discovered and primary tumors often produce few symptoms.